Category: Pharmacy

  • Download PDF by Gail Sofer: Process Validation in Manufacturing of Biopharmaceuticals:

    By Gail Sofer

    ISBN-10: 0824702492

    ISBN-13: 9780824702496

    ISBN-10: 1420001655

    ISBN-13: 9781420001655

    ISBN-10: 1574445162

    ISBN-13: 9781574445169

    Written through skilled specialists in method validation, method Validation in production of Biopharmaceuticals explores present traits within the box and techniques for the choice of the main applicable qc scheme. It deals useful instructions, techniques, and an abundance of commercial case stories that exhibit quite a few strategies and ways within the validation of biopharmaceutical strategies.

    Provides particular examples of failure modes and impression research (FMEA) that assist you determine this system on your association
    Show description

  • Read e-book online Bioactive Heterocyclic Compound Classes: Pharmaceuticals PDF

    By Clemens Lamberth, J?rgen Dinges

    ISBN-10: 3527333959

    ISBN-13: 9783527333950

    ISBN-10: 3527664459

    ISBN-13: 9783527664450

    The chemistry of heterocycles is a vital department of natural chemistry. this can be for the reason that quite a few common items, e. g.
    hormones, antibiotics, supplements, and so on. are composed of heterocyclic constructions. usually, those compounds exhibit gains and are accordingly utilized as prescription drugs to regard illnesses or as pesticides, herbicides or fungicides in crop protection.
    This quantity provides vital prescribed drugs. all the 20 chapters covers in a concise demeanour one type of heterocycles, basically structuredas follows:

    * Structural formulation of most vital examples (market products)
    * brief history of historical past or discovery
    * usual syntheses of vital examples
    * Mode of action
    * attribute organic activity
    * Structure-activity relationship
    * extra chemistry details (e.g. additional adjustments, replacement syntheses, metabolic pathways, etc.)
    * References.

    A worthy one-stop reference resource for researchers in academia and in addition to for graduate scholars with profession aspirations in the
    pharmaceutical chemistry.Content:
    Chapter 1 the importance of Heterocycles for prescribed drugs and Agrochemicals (pages 1–20): Dr. Clemens Lamberth and Dr. Jurgen Dinges
    Chapter 2 Tropane?Based Alkaloids as Muscarinic Antagonists for the therapy of bronchial asthma, Obstructive Pulmonary ailment, and movement disorder (pages 21–36): Michael L. Schulte and Craig W. Lindsley
    Chapter three Morphinone?Based Opioid Receptor Agonist Analgesics (pages 37–49): Stephanie M. Ng
    Chapter four Barbituric Acid?Based GABA(A) Receptor Modulators for the remedy of sleep problem and Epilepsy and as Anesthetics (pages 51–64): Ingo Janser and Romy Janser
    Chapter five Phenothiazine?Based Dopamine D2 Antagonists for the therapy of Schizophrenia (pages 65–79): Cristiana A. Zaharia
    Chapter 6 Arylpiperazine?Based 5?HT1A Receptor Partial Agonists and 5?HT2A Antagonists for the remedy of Autism, melancholy, anxiousness, Psychosis, and Schizophrenia (pages 81–97): Irini Akritopoulou?Zanze
    Chapter 7 Arylpiperidine?Based Dopamine D2 Antagonists/5?HT2A Antagonists for the remedy of Autism, melancholy, Schizophrenia, and Bipolar illness (pages 99–114): Ying Wang
    Chapter eight Dibenzazepine?Based Sodium Channel Blockers for the remedy of Neuropathic ache (pages 115–133): Derek W. Nelson
    Chapter nine Dihydropyridine?Based Calcium Channel Blockers for the remedy of Angina Pectoris and high blood pressure (pages 135–151): Milan Bruncko
    Chapter 10 Tetrazole?Based Angiotensin II variety 1 (AT1) Antagonists for the therapy of middle Failure and Congestive high blood pressure (pages 153–167): Edward C. Lawson, Brian C. Shook and James C. Lanter
    Chapter eleven Thiazide?Based Diuretics for the therapy of high blood pressure and Genitourinary problems (pages 169–182): Dr. Jurgen Dinges
    Chapter 12 Tetrahydropyranone?Based HMG?CoA Reductase Inhibitors for the remedy of Arterial Hypercholesterolemia (pages 183–200): Hongyu Zhao
    Chapter thirteen Adenine?Based opposite Transcriptase Inhibitors as Anti?HIV brokers (pages 201–216): Alastair Donald
    Chapter 14 Guanine?Based Nucleoside Analogs as Antiviral brokers (pages 217–236): Maurizio Franzini
    Chapter 15 Penicillin and Cephalosporin Antibiotics (pages 237–253): Michael Z. Hoemann
    Chapter sixteen Pyrimidine?Based Kinase Inhibitors in melanoma Chemotherapy (pages 255–273): Robert Mah
    Chapter 17 Benzyl Triazole?Based Aromatase Inhibitors for the remedy of Breast melanoma (pages 275–287): sunrise George and Stacy Van Epps
    Chapter 18 Acetonide?Based Glucocorticoids for the therapy of bronchial asthma, epidermis irritation, and illnesses of the attention (pages 289–312): Kevin P. Cusack, Vikram G. Kalthod, Rajarathnam E. Reddy and Sanjay R. Chemburkar
    Chapter 19 Benzimidazole?Based H+/K+?ATPase Inhibitors for the therapy of Gastroesophageal Reflux sickness (pages 313–326): Steve Swann
    Chapter 20 Thiazolidinedione?Based Insulin Sensitizers:PPAR?? Agonists for the therapy of variety 2 Diabetes (pages 327–347): Steven Richards
    Show description

  • Get Co-occurring Addictive and Psychiatric Disorders: A PDF

    By Geert Dom, Franz Moggi

    ISBN-10: 3642453740

    ISBN-13: 9783642453748

    ISBN-10: 3642453759

    ISBN-13: 9783642453755

    This booklet presents a accomplished, cutting-edge assessment that covers either the prognosis and the therapy of twin problems – joint psychiatric and substance use problems linked to a worse final result and sickness development than unmarried psychiatric or addictive issues. The ebook is designed to be hugely appropriate to scientific paintings and the association of care platforms and meets the true want for a eu viewpoint on twin problems that takes under consideration the realities of ecu therapy association. All chapters were written by means of ecu authors at the foundation of present eu remedy courses or instructions and ecu learn. The e-book can be priceless for all well-being pros operating in psychological healthiness and habit care, who're more and more faced with sufferers struggling with twin disorders.

    Show description

  • Download e-book for iPad: Pharmaceutical excipients : properties, functionality, and by Otilia M. Y. Koo

    By Otilia M. Y. Koo

    ISBN-10: 1118992415

    ISBN-13: 9781118992418

    ISBN-10: 1118992431

    ISBN-13: 9781118992432

    This booklet presents an outline of excipients, their functionalities in pharmaceutical dosage kinds, legislation, and choice for pharmaceutical items formula. It comprises improvement, characterization method, functions, and updated advances during the views of excipients builders, clients, and regulatory experts.

    • Covers the resources, characterization, and harmonization of excipients: crucial info for optimum excipients choice in pharmaceutical development
    • Describes the physico-chemical homes and organic results of excipients
    • Discusses chemical periods, defense and toxicity, and formulation
    • Addresses contemporary efforts within the standardization and harmonization of excipients
    Show description

  • John A. Bontempo's Development of biopharmaceutical parenteral dosage forms PDF

    By John A. Bontempo

    ISBN-10: 082479981X

    ISBN-13: 9780824799816

    This up to the moment reference delineates-in a scientific fashion-the acceptable, sequential steps for the formula of secure, potent, good, and marketable liquid parenteral biopharmaceutical products-covering basics and crucial pathways for every part in addition to its function, functionality, and relation to different levels within the product improvement strategy. Written via specialists presently focused on cutting-edge advances within the pharmaceutical drug undefined, improvement of Biopharmaceutical Parenteral Dosage varieties ·details biopharmaceuticals which are approved or present process medical improvement, together with genetically engineered mobile and engineered vectors within the fermentation approach ·describes purification and characterization thoughts for rDNA therapeutics, discussing different types of unit operations for isolation, purification, and characterization ·considers preformulation and formula specifications, akin to physicochemical homes, drug supply, balance reviews courses, deactivation/denaturation routes, collection of appropriate excipients, and regulatory compliance ·elucidates fundamentals of analytical options, equipment improvement, separation tools utilizing chromatographic and electrophoretic thoughts, and bioactivity equipment overlaying bioassays and immunoassays for quantifying the steadiness of organic job ·shows tips to decide on the correct filter out for maximizing compatibility and minimizing adsorption and inactivation, analyzing subject matters from easy filtration theories to destiny traits ·reviews the choice procedure for suitable elastomeric closures, studying actual, chemical, toxicological houses, protein adsorption on elastomeric surfaces, ideas to reduce/eliminate adsorption, and really good packing containers for biotechnological purposes ·and extra! provided with worthwhile references, tables, and drawings, this functional advisor is necessary for pharmaceutical, medicinal, and protein chemists; molecular biologists; strategy engineers; purification scientists; biopharmaceutical and pharmaceutical formulators and product builders; quality controls, caliber coverage, and regulatory compliance group of workers; and upper-level undergraduate and graduate scholars in those disciplines.
    Show description

  • Download e-book for kindle: Buying rx drugs online: avoiding a prescription for disaster by Kate J. Chase

    By Kate J. Chase

    ISBN-10: 159200671X

    ISBN-13: 9781592006717

    The net supplies a number of cost-saving choices for the acquisition of prescribed drugs. with out sufficient info, even if, it may possibly even be a deadly replacement. "Buying Rx medicinal drugs on-line" serves as a sensible buyer advisor for an individual who's contemplating going surfing for medicines. It covers the entire variety of the net pharmaceutical event, explaining either the advantages and the hazards, in addition to why doctors can be stored within the loop. It examines the ease and results of shopping for prescription-and even a few non-prescription-medication in the course of the net. It bargains beneficial guidance and suggestion concerning what to seem for in judging the legitimacy of those websites and the way you could determine the medicinal drugs you obtain.
    Show description

  • Validated Cleaning Technologies for Pharmaceutical by Destin A. LeBlanc PDF

    By Destin A. LeBlanc

    ISBN-10: 1574911163

    ISBN-13: 9781574911169

    Written by means of knowledgeable should you needs to layout validatable cleansing methods after which validate these approaches, this publication discusses interdependent subject matters from numerous technical parts and disciplines. It exhibits how every bit of the cleansing technique suits into the validation application, making it extra defensible in either inner caliber audits and exterior regulatory audits. Designed to be used within the total validation software, the publication demonstrates the right way to construct a entire software, and contains dialogue and examples of cleansing structures, regulatory requisites, and unique themes and matters. It presents an FDA cleansing validation assistance rfile and a entire word list.
    Show description

  • The Quest for the Cure: The Science and Stories Behind the by Brent Stockwell PDF

    By Brent Stockwell

    ISBN-10: 0231152124

    ISBN-13: 9780231152129

    ISBN-10: 0231525524

    ISBN-13: 9780231525527

    After greater than fifty years of blockbuster drug improvement, skeptics are starting to worry we're attaining the top of drug discovery to wrestle significant ailments. during this enticing booklet, Brent R. Stockwell, a number one researcher within the fascinating new technological know-how of chemical biology, describes this problem and the robust suggestions which could deliver drug learn into the twenty-first century.Filled with soaking up tales of breakthroughs, this e-book starts with the medical achievements of the 20 th century that resulted in state-of-the-art drug concepts. We learn the way the discovery of mustard fuel in international struggle I ended in early anti-cancer brokers and the way the efforts to decode the human genome may possibly bring about new ways in drug layout. Stockwell then turns to the possible incurable ailments we are facing this day, reminiscent of Alzheimer's, many cancers, and others without really potent medications, and information the mobile and molecular boundaries thwarting scientists outfitted with in basic terms the instruments of conventional pharmaceutical study. Scientists akin to Stockwell are actually constructing how to wrestle those complexities—technologies for developing and trying out hundreds of thousands of drug applicants, subtle computational modeling, and fully new periods of drug molecules—all with a watch towards fixing the main profound mysteries of dwelling structures and discovering therapies for intractable ailments. If winning, those tools will release an unlimited terrain of untapped drug ambitions which can result in a bounty of step forward medicinal drugs. supplying a unprecedented, behind-the-scenes examine this state of the art study, the search for the remedy tells an exhilarating tale of technological know-how, endurance, and the hunt to enhance a brand new new release of treatments. (4/4/2011)
    Show description

  • Read e-book online The Chemistry and Applications of Sustainable Natural Hair PDF

    By Kalyani Barve, Apurva Dighe

    ISBN-10: 3319294172

    ISBN-13: 9783319294179

    ISBN-10: 3319294199

    ISBN-13: 9783319294193

    This publication investigates the connection among phytoconstituents and houses in particular crops, akin to Hibiscus rosa sinesis, Cuscuta reflexa, Citrullus colocynthis, Nardostachys jatamansi and Ocimum gratissimum, which are utilized in hair care items together with shampoos, conditioners, dyes, and oils. It explains the impression of those fabrics at the development, constitution, visual appeal, and future health of hair. It additionally explores how the chemistry of definite vegetation from sustainable resources is exploited to be used in hair items and nutraceuticals. also, the authors comprise details on components used for formulating 'green' hair items that deal with universal stipulations similar to canities, dandruff and alopecia.

    Show description

  • Read e-book online Chemical Process Research. The Art of Practical Organic PDF

    By Ahmed F. Abdel-Magid, John A. Ragan

    ISBN-10: 0841219753

    ISBN-13: 9780841219755

    ISBN-10: 0841238243

    ISBN-13: 9780841238244

    This booklet indicates the range of structural difficulties and synthesis resolution in addition to the sensible elements and methodologies required for large-scale syntheses. The 11 chapters concentrate on chemical approach examine within the pharmaceutical industry.
    Show description