Read e-book online Chemical Process Research. The Art of Practical Organic PDF

By Ahmed F. Abdel-Magid, John A. Ragan

ISBN-10: 0841219753

ISBN-13: 9780841219755

ISBN-10: 0841238243

ISBN-13: 9780841238244

This booklet indicates the range of structural difficulties and synthesis resolution in addition to the sensible elements and methodologies required for large-scale syntheses. The 11 chapters concentrate on chemical approach examine within the pharmaceutical industry.

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Cardozo, M . ; Frye, L. ; Grygon, C. ; Hopkins, J. ; Jeanfavre, D. ; Stevenson, J. M . ; Kelly, T. A. J. Am. Chem. Soc. 2001, 123, 5643. 3. , M . D. Tetrahedron Asymmetry 1998, 9, 3517. 4. , Practical Process Research and Development. Academic Press, San Diego, CA, 2000. 5. ;Blythe, T. ; McNabb, T. ; Walts, A. E. J. Org. Chem. 1992, 57, 3525. 6. , Kapadia, S. R. J. Org. Chem. 1996, 61, 7398. 7. Yee, N . Org. Lett. 2000, 2, 2781. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003.

Kuhnle, F. N . M . ; Seebach, D. Liebigs Ann. Chem. 1997, 1697. ; Comar, D. Tetrahedron 1997, 53, 5785. ; Yee, N . Tetrahedron: Asymmetry 2001, 12, 101. ; Spero, D. M . ; Eriksson, M . J. Org Chem. 2001, 1903. ; Meckstroth, W. Chem. Ber. 1959, 92, 1675. ; Rapoport, H. J. Am. Chem. Soc. 1981, 103, 6157. ; Witty, M . J. J. Chem. Soc. 11979, 3203. Neuenschwander, M . ; Mühle, H. Helv. Chim. Acta 1978, 61 (6), 2047. ; Farina, V. Tetrahedron Lett. 2001, 42, 3231. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003.

It was then found in both cases that a crystallization­ -driven dynamic transformation can produce, in a very efficient manner, the desired cis isomer in virtually 100% selectivity in the case of 29d, whereas only the trans isomer is obtained in the case of 16. 9% ee via two separate processes. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2003. [i, 2] The structure of the target compound is simple and the only synthetic challenge is presented by the presence of a chiral quaternary center.

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Chemical Process Research. The Art of Practical Organic Synthesis by Ahmed F. Abdel-Magid, John A. Ragan


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