Endocrine Disruptors Part II (Handbook of Environmental - download pdf or read online
By M. Metzler
ISBN-10: 3540422803
ISBN-13: 9783540422808
The sector of endocrine disruption or endocrine energetic compounds (EACs), that is simply rising and nonetheless arguable, is comprehensively lined by means of top specialists in quantity three, Subvolumes L (Part I) and M (the current quantity, half II). the main periods of endocrine energetic chemical substances are mentioned, in addition to equipment for his or her detection and their organization with healthiness disturbances in people and natural world. The etiology of a number of of the human ailments linked to endocrine disruptors, e.g. breast and prostate melanoma, reduced fertility and malformations, continues to be poorly understood, and the present kingdom of information is gifted. for the reason that hormonally lively brokers seem to have the possibility of either antagonistic and important results, the proof of future health merits linked to endocrine energetic compounds in people is additionally awarded. simple chapters at the mode of motion of EACs and at the etiology of the linked illnesses facilitate the knowledge of this complicated topic for non-medical readers.
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Additional resources for Endocrine Disruptors Part II (Handbook of Environmental Chemistry)
Example text
However, it is unlikely that life style is the sole factor that explains the differences in prostate cancer risk between Asian and American populations [10, 135]. The single most important combination of risk factors is to be of sub-Saharan African descent and to reside in the US – African Americans have, as a group, twice the risk of white Americans. The reasons for the black-white disparity in prostate cancer rates in the US are not understood. While genetic factors, such as genetically determined elevated 5a-reductase activity, are possibly involved, environmental exposures (in the broadest sense of the term) are probably responsible for a large fraction of this disparity [10, 13, 17, 189].
Most studies indicate that a high intake of fat, particularly total fat and saturated fat, is a risk factor for prostate cancer, but the strength of the associations is modest [57] and may be greater in African Americans than European Americans [58]. As much as 25% of prostate cancer in the US may be attributable to a high saturated fat intake [59]. However, Whittemore et al. [22] estimated that dietary fat intake may account for only 10–15% of the difference in prostate cancer occurrence between European Americans and African Americans or Asians.
These finding perhaps suggest an inverse relation between 5a-reductase activity and prostate cancer risk. Heikkilä et al. [174] conducted a population-based nested case-control study in a Finnish cohort study where serum was collected and stored from a cohort of 16,481 men which was followed for up to 24 years. Over this period 166 prostate cancer cases were identified and 300 matched controls were obtained from the cohort. There were no differences between cases and control and there was association with prostate cancer risk for serum levels of testosterone, SHBG, and androstenedione.
Endocrine Disruptors Part II (Handbook of Environmental Chemistry) by M. Metzler
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