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By A. Dubois (auth.), Professor Dr. Hughes Baumel, Dr. Bernard Deixonne (eds.)

ISBN-10: 0387165304

ISBN-13: 9780387165301

ISBN-10: 3642711782

ISBN-13: 9783642711787

ISBN-10: 3642711804

ISBN-13: 9783642711800

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Both of these lesions may appear in the same gland. In such a case, it is impossible, when presented with a surgical specimen of pancreatic cancer associated with pancreatitis, to decide which of the lesions is primary, and it is an open question whether a pancreatitis-cancer relation is possible. We will then proceed in this chapter to describe pancreatic lesions whose origin appears to be secondary to the developing cancer. The precancerous lesions will be discussed under duct hyperplasia-carcinoma relations.

Poorly differentiated duct adenocarcinoma. x 52 Giant cell adenocarcinoma is rarely observed. However, this is a classical and very well-known tumor: on observing a distant metastasis of giant-cell type, the pathologist always suggests the pancreas as the possible site of origin. This tumor presents two different aspects. The pleomorphic form (4% of cases) has preferentially a cephalic topography, but localizations in the tail and the body of the pancreas are sometimes found as well. Macroscopically, the excavated tumor is voluminous, presenting a pseudocystic aspect with necrotic-hemorrhagic material inside.

A last cellular type is represented by small, round elements of regular morphology, with a pale cytoplasm, arranged in clumps or clusters, and rich in mitoses. The special coloration portrays a mucin secretion in the pseudoglandular structures, more rarely found in giant cell cytoplasm. The giant cell adenocarcinoma, epulis type. astoma, even more rare (1%), appears to be a more differentiated form [14] and results in a less severe prognosis [37]. The giant cells are predominant, they range from monstrous giant cells (as in the pleomorphic carcinoma described above) to the osteoclastic type of plasmode (non-atypic, with no malignant appearance).

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Exocrine Pancreatic Cancer by A. Dubois (auth.), Professor Dr. Hughes Baumel, Dr. Bernard Deixonne (eds.)


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