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Extra info for Imaging and Visualization in The Modern Operating Room: A Comprehensive Guide for Physicians

Example text

Another contrast agent, indocyanine green (ICG), has been approved for sentinel lymph node mapping, tumor resection, and determination of cardiac output and hepatic function. During the past decade, there has been significant progress in the development of optimized and targeted NIR fluorophores for in vivo intraoperative molecular imaging as an image-guided surgical tool in preclinical research and clinical trials. Since fluorescence imaging is relevant for tissues close to the surface of skin, or tissues accessible by endoscopy and intraoperative visualization, it is a vital for fluorophores to have minimal interferential absorption and refraction, low biological autofluorescence, and high tissue penetration.

Oral Oncol. 2013;49:15–9. 37. Yamashita S, Tokuishi K, Miyawaki M, Anami K, Moroga T, Takeno S, et al. Sentinel node navigation surgery by thoracoscopic fluorescence imaging system and molecular examination in non-small cell lung cancer. Ann Surg Oncol. 2012;19:728–33. 38. Crane LMA, Themelis G, Arts HJG, Buddingh KT, Brouwers AH, Ntziachristos V, et al. Intraoperative near-infrared fluorescence imaging for sentinel lymph node detection in vulvar cancer: first clinical results. Gynecol Oncol. 2011;120:291–5.

13. Von Breitenbuch P, Jeiter T, Schreml S, Glockzin G, Agha A, Piso P, et al. Autofluorescent imaging in patients with peritoneal carcinomatosis. Surg Innov. 2014;21:187–93. 14. Buchweitz O, Staebler A, Tio J, Kiesel L. Detection of peritoneal endometriotic lesions by autofluorescence laparoscopy. Am J Obstet Gynecol. 2006;195:949–54. 15. Jacobson MC, deVere White R, Demos SG. In vivo testing of a prototype system providing simultaneous white light and near infrared autofluorescence image acquisition for the detection of bladder cancer.

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