Microwave-assisted synthesis of heterocycles - download pdf or read online
By Nils Pemberton, Erik Chorell (auth.), Erik Van der Eycken, C. Oliver Kappe (eds.)
ISBN-10: 3540309837
ISBN-13: 9783540309833
This booklet is quantity I of a brand new sequence by means of Springer entitled themes in Heterocyclic Chemistry. at the moment, there are six such monographs during this sequence, the general scope of that is to hide "current tendencies in heterocyclic chemistry". Given the significance of heterocylic common items and heterocyclic scaffolds within the realm of medicinal chemistry and drug discovery, an up-todate sequence in this topic is easily warranted, and a survey of the hot effect of microwave-assisted synthesis in this venerable box is either well timed and needed...........
Overall, it is a good thoughtout, updated, and informative textual content written via the numerous of the leaders during this rising box. whereas the editors and authors have performed an admirable task of providing a photo of the present nation of microwave-assisted heterocyclic chemistry, they've got additionally uncovered the truth that a lot is still performed during this sector, a feat that could be comprehensive whilst this robust approach has completed better popularity. ultimately, even supposing the booklet of this quantity coincides with the advent of a number of first-class monographs on microwave chemistry to the industry, the worth of the current textual content isn't really reduced via those extra complete surveys of the subject, during which the insurance of heterocyles is sometimes restricted to a unmarried bankruptcy.
Daniel M. Ketcha, Wright kingdom college, JA0697626, 10.1021/ja0697626, 14416 J. AM. CHEM. SOC. nine VOL. 128, NO. forty four, 2006
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Example text
56 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Abstract Multicomponent reactions offer convenient procedures for the introduction of many points of structural diversity into heterocyclic compounds prepared in a straightforward manner in a single synthetic step. Combining these features with the extremely fast reaction kinetics of microwave-assisted organic synthesis provides new methods for the rapid and efficient synthesis of heterocyclic libraries suitable for biological evaluation and SAR studies.
In the following section, a variety of C – C and C – N cross-coupling reactions under microwave-assisted conditions are described with some illustrative examples. 1 Suzuki Coupling The Suzuki reaction has been successfully used to introduce new C – C bonds into 2-pyridones [75, 83, 84]. The use of microwave irradiation in transitionmetal-catalyzed transformations is reported to decrease reaction times [52]. Still, there is, to our knowledge, only one example where a microwaveassisted Suzuki reaction has been performed on a quinolin-2(1H)-one or any other 2-pyridone containing heterocycle.
Selective C4 monochlorination can be accomplished when the reaction is performed with N1-substituted 2-quinolones, however, when performing the transformation on N-unsubstituted 2-quinolones both the 2 and Scheme 11 Chloro dehydroxylation of 4-hydroxy-2-quinolones under microwave irradiation 18 N. Pemberton et al. 4 positions are chlorinated. A well-designed route to solve this problem was reported by Glasnov et al. who used a microwave-assisted two-step chlorination/hydrolysis sequence to get the monochlorinated product 39 in high yield (b, Scheme 11).
Microwave-assisted synthesis of heterocycles by Nils Pemberton, Erik Chorell (auth.), Erik Van der Eycken, C. Oliver Kappe (eds.)
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