Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell by Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, PDF

By Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)

ISBN-10: 1461458935

ISBN-13: 9781461458937

ISBN-10: 1461458943

ISBN-13: 9781461458944

​​​​​​​Prominin-1 or in a different way referred to as CD133 is a glycoprotein that's found in people and mice. because the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a wide curiosity specially, as a stem mobile marker, that gave upward push to an ever becoming physique of guides and extra lately its expression in melanoma stem cells. Controversies as to its function as a melanoma stem and its detection in numerous versions, in addition to its use as a prognostic marker have emerged. but, past its use as a stem phone and melanoma stem mobilephone marker, prominin-1/CD133 monitors specified organic good points and looks of significance in different tactics like for instance in retinal biogenesis. certainly, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is linked to a number of crucial tactics like phone polarity, uneven phone department and membrane home improvement. we recommend to check present wisdom approximately this exciting molecule and current pertinent info to figure out the organic position of prominins and check their value in drugs and melanoma learn. the first viewers for this ebook is geared in the direction of scientists and researchers with curiosity in melanoma stem cells, stem cells, mobile biology, neurobiology, and regenerative medicine.

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Additional resources for Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

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Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA (2001) Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 98:10716–10721 65. Carpenter MK, Rosler E, Rao MS (2003) Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells 5:79–88 66. Hoffman LM, Carpenter MK (2005) Characterization and culture of human embryonic stem cells. Nat Biotechnol 23:699–708 67. Shamblott MJ, Axelman J, Littlefield JW, Blumenthal PD, Huggins GR et al (2001) Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro.

Huttner HB, Janich P, Köhrmann M, Jászai J, Siebzehnrubl F et al (2008) The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying CNS disease. Stem Cells 26:698–705 62. Huttner HB, Corbeil D, Thirmeyer C, Coras R, Köhrmann M et al (2012) Increased membrane shedding–indicated by an elevation of CD133-enriched membrane particles – into the CSF in partial epilepsy. Epilepsy Res 99:101–106 63. Kania G, Corbeil D, Fuchs J, Tarasov KV, Blyszczuk P et al (2005) The somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors.

97. Lin EH, Hassan M, Li Y, Zhao H, Nooka A et al (2007) Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence. Cancer 110:534–542 98. Hilbe W, Dirnhofer S, Oberwasserlechner F, Schmid T, Gunsilius E et al (2004) CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer. J Clin Pathol 57:965–969 99. Dome B, Timar J, Dobos J, Meszaros L, Raso E et al (2006) Identification and clinical significance of circulating endothelial progenitor cells in human non-small cell lung cancer.

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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology by Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)


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